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Article

UTP11 deficiency suppresses cancer development via nucleolar stress and ferroptosis

21 Apr 2023

Abstract excerpt

The eukaryotic ribosome is essential for cancer cell survival. Perturbation of ribosome biogenesis induces nucleolar stress or ribosomal stress, which restrains cancer growth, as rapidly proliferating cancer cells need more active ribosome biogenesis. In this study, we found that UTP11 plays an important role in the biosynthesis of 18S ribosomal RNAs (rRNA) by binding to the pre-rRNA processing factor, MPP10....

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Share to Epigenetics and DNA Methylation
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PMID: 37087976
DOI: 10.1016/j.redox.2023.102705

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