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Article

A Clinical Rule for Preoperative Prediction of BRAF Mutation Status in Craniopharyngiomas

12 Nov 2018

Abstract excerpt

BACKGROUND: Papillary craniopharyngiomas are characterized by BRAFV600E mutations. Targeted therapy can elicit a dramatic radiographic regression of these tumors. Therefore, prediction of BRAF mutation status before definitive surgery could enable neoadjuvant treatment strategies. OBJECTIVE: To establish preoperative prediction criteria to identify patients with a BRAF mutant craniopharyngioma. METHODS:...

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PMID: 30481321
DOI: 10.1093/neuros/nyy569

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