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Article

Do craniopharyngioma molecular signatures correlate with clinical characteristics?

Journal of neurosurgery - 1 May 2018

Omay Sacit Bulent, Chen Yu-Ning, Almeida Joao Paulo, Ruiz-Treviño Armando Saul, Boockvar John A, Stieg Philip E, Greenfield Jeffrey P, Souweidane Mark M, Kacker Ashutosh, Pisapia David J, Anand Vijay K, Schwartz Theodore H

Abstract excerpt

OBJECTIVE Exome sequencing studies have recently demonstrated that papillary craniopharyngiomas (PCPs) and adamantinomatous craniopharyngiomas (ACPs) have distinct genetic origins, each primarily driven by mutually exclusive alterations: either BRAF ( V600E), observed in 95% of PCPs, or CTNNB1, observed in 75%-96% of ACPs. How the presence of these molecular signatures, or their absence, correlates with clinical,...

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Identifiers

PMID: 28707994
DOI: 10.3171/2017.1.JNS162232

Genes

BRAF
CTNNB1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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