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Immunohistochemistry or Molecular Analysis: Which Method Is Better for Subtyping Craniopharyngioma?

Endocrine pathology - 1 Jun 2021

Fukuhara Noriaki, Iwata Takeo, Inoshita Naoko, Yoshimoto Katsuhiko, Kitagawa Masanobu, Fukuhara Hirokazu, Tatsushima Keita, Yamaguchi-Okada Mitsuo, Takeshita Akira, Ito Junko, Takeuchi Yasuhiro, Yamada Shozo, Nishioka Hiroshi

Abstract excerpt

Craniopharyngioma (CP) is mainly classified into two pathological subtypes: adamantinomatous (ACP) and papillary (PCP). CTNNB1 (β-catenin) mutations are detected in ACPs, and the BRAF V600E mutation is detected in PCPs. However, genetic analysis is not always possible in general medical practice. In this study, we investigated whether immunohistochemistry could replace genetic analysis as an aid in subtype...

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beta Catenin
Biomarkers, Tumor
Child, Preschool
Craniopharyngioma
Immunohistochemistry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Pituitary Neoplasms

Proto-Oncogene Proteins B-raf

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PMID: 32965631
DOI: 10.1007/s12022-020-09644-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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