Article
Diagnosis and management of craniopharyngiomas in the era of genomics and targeted therapy.
Neurosurgical focus - 1 Dec 2016
Martinez-Gutierrez Juan Carlos, D'Andrea Megan R, Cahill Daniel P, Santagata Sandro, Barker Fred G, Brastianos Priscilla K
Abstract excerpt
Craniopharyngiomas are rare intracranial neoplasms that pose clinical challenges due to their location adjacent to vital structures. The authors have previously shown high mutation rates of BRAF V600E in papillary craniopharyngioma and of CTNNB1 in adamantinomatous craniopharyngioma. These activating driver mutations are potential therapeutic targets, and the authors have recently reported a significant response...
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