Article

Study protocol for preoperative classification using integrated screening and short-course neoadjuvant BRAF/MEK inhibition in newly diagnosed papillary craniopharyngioma (the PRECISE-PCP study): a prospective single-arm study

2026-05-12

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Introduction</h4> Craniopharyngioma (CP) comprises two distinct histological subtypes, adamantinomatous craniopharyngioma (ACP) and papillary craniopharyngioma (PCP), which are often challenging to distinguish preoperatively. Approximately 95% of PCP harbor the BRAF V600E mutation, whereas ACP lacks this alteration, making PCP uniquely sensitive to BRAF and MEK inhibition. However, in the a...

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Literature Corpus work: 5d5da094-20f2-5f2f-8948-9e460258cfec
DOI: 10.64898/2026.05.08.26351826

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Study protocol for preoperative classification using integrated screening and short-course neoadjuvant BRAF/MEK inhibition in newly diagnosed papillary craniopharyngioma (the PRECISE-PCP study): a prospective single-arm studyDOI 10.64898/2026.05.08.26351826Read

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