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Article

Clinical Relevance of BRAF V600E Mutation Status in Brain Tumors with a Focus on a Novel Management Algorithm.

Targeted oncology - 1 Aug 2020

Kowalewski Adam, Durślewicz Justyna, Zdrenka Marek, Grzanka Dariusz, Szylberg Łukasz

Abstract excerpt

The possible application of BRAF-targeted therapy in brain tumors is growing continuously. We have analyzed clinical strategies that address BRAF activation in primary brain tumors and verified current recommendations regarding screening for BRAF mutations. There is preliminary evidence for a range of positive responses in certain brain tumor types harboring the BRAF V600E mutation. National Comprehensive Cancer...

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PMID: 32648041
DOI: 10.1007/s11523-020-00735-9
PMCID: PMC7434793

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