Recurrent MED12 exon 2 mutations in benign breast fibroepithelial lesions in adolescents and young adults

Abstract excerpt

Aims Most benign breast fibroepithelial lesions (FEL) in adults harbour recurrent somatic MED12 exon 2 mutations and rare TERT promoter hotspot mutations. We sought to determine the frequency of MED12 exon 2 and TERT promoter hotspot mutations in fibroadenomas (FA) and benign phyllodes tumours (BePT) in adolescents and young adults. Methods DNA from 21 consecutive FAs and eight consecutive BePTs in adolescents...

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