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Article

Stromal MED12 exon 2 mutations in complex fibroadenomas of the breast.

Journal of clinical pathology - 1 Feb 2022

da Silva Edaise M, Beca Francisco, Sebastiao Ana Paula Martins, Murray Melissa P, Silveira Catarina, Da Cruz Paula Arnaud, Pareja Fresia, Wen Hannah Y, D'Alfonso Timothy M, Edelweiss Marcia, Weigelt Britta, Brogi Edi, Reis-Filho Jorge S, Zhang Hong

Abstract excerpt

AIMS: Here we explore the presence of mediator complex subunit 12 (MED12) exon 2 and telomerase reverse transcriptase (TERT) promoter hotspot mutations in complex fibroadenomas (CFAs) of the breast. METHODS: The stromal components from 18 CFAs were subjected to Sanger sequencing of MED12 exon 2 and the TERT promoter hotspot loci. The epithelial and stromal components of two MED12 mutated CFAs were subjected to...

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Source

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Identifiers

PMID: 33376197
DOI: 10.1136/jclinpath-2020-207062
PMCID: PMC8260148

Genes

MED12
TERT
PIK3CA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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