Article
MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways.
Oncotarget - 20 Dec 2016
Laé Marick, Gardrat Sophie, Rondeau Sophie, Richardot Camille, Caly Martial, Chemlali Walid, Vacher Sophie, Couturier Jérôme, Mariani Odette, Terrier Philippe, Bièche Ivan
Abstract excerpt
Exome sequencing has recently identified highly recurrent MED12 somatic mutations in fibroadenomas (FAs) and phyllodes tumors (PTs). In the present study, based on a large series, we confirmed the presence of MED12 exon 1 and 2 mutations in 49% (41/83) of PTs, 70% (7/10) of FAs and 9.1% (1/11) of fibromatoses. We show that MED12 mutations are associated with benign behavior of phyllodes tumors, as they are...
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