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Article

MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast.

Histopathology - 1 Nov 2015

Piscuoglio Salvatore, Murray Melissa, Fusco Nicola, Marchiò Caterina, Loo Florence L, Martelotto Luciano G, Schultheis Anne M, Akram Muzaffar, Weigelt Britta, Brogi Edi, Reis-Filho Jorge S

Abstract excerpt

AIMS: Somatic mutations in exon 2 of the mediator complex subunit 12 (MED12) gene have been identified in 60% of breast fibroadenomas (FAs). The aim of this study was to define whether phyllodes tumours (PTs) would harbour MED12 somatic mutations in a way akin to FAs. METHODS AND RESULTS: A collection of 73 fibroepithelial tumours (including 26 FAs, 25 benign PTs, nine borderline PTs and 13 malignant PTs) from 64...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25855048
DOI: 10.1111/his.12712
PMCID: PMC4996373

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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MED12 somatic mutations in fibroadenomas and phyllodes tumours of the breast.PMID 25855048Read ↗

Frequent MED12 mutations in phyllodes tumours of the breast.Semantic proximity Read ↗

MED12 is frequently mutated in breast phyllodes tumours: a study of 112 cases.Semantic proximity Read ↗

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.Semantic proximity Read ↗

MED12 exon 2 mutations in phyllodes tumors of the breast.Semantic proximity Read ↗

Mutational analysis of MED12 in fibroadenomas and phyllodes tumors of the breast by means of targeted next-generation sequencing.Semantic proximity Read ↗

Molecular pathology of phyllodes tumours of the breast-much more than MED12.Semantic proximity Read ↗

Distribution of MED12 mutations in fibroadenomas and phyllodes tumors of the breast--implications for tumor biology and pathological diagnosis.Semantic proximity Read ↗

MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways.Semantic proximity Read ↗

Next-Gen Sequencing Exposes Frequent MED12 Mutations and Actionable Therapeutic Targets in Phyllodes Tumors.Semantic proximity Read ↗

Mutational analysis of MED12 exon 2 in a spectrum of fibroepithelial tumours of the breast: implications for pathogenesis and histogenesis.Semantic proximity Read ↗

Genetics and genomics of breast fibroadenomas.Semantic proximity Read ↗

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