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Germline genetic variation and predicting immune checkpoint inhibitor induced toxicity

24 Dec 2022

Abstract excerpt

Immune checkpoint inhibitor (ICI) therapy has revolutionised the treatment of various cancer types. ICIs reinstate T-cell function to elicit an anti-cancer immune response. The resulting immune response can however have off-target effects which manifest as autoimmune type serious immune-related adverse events (irAE) in ~10-55% of patients treated. It is currently challenging to predict both who will experience...

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PMID: 36564402
DOI: 10.1038/s41525-022-00345-6

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