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Article

Sex differences in insulin resistance, but not peripheral neuropathy, in a diet-induced prediabetes mouse model.

Disease models & mechanisms - 1 Apr 2021

Elzinga Sarah E, Savelieff Masha G, O'Brien Phillipe D, Mendelson Faye E, Hayes John M, Feldman Eva L

Abstract excerpt

Peripheral neuropathy (PN) is a common complication of prediabetes and diabetes and is an increasing problem worldwide. Existing PN treatments rely solely on glycemic control, which is effective in type 1 but not type 2 diabetes. Sex differences in response to anti-diabetic drugs further complicate the identification of effective PN therapies. Preclinical research has been primarily carried out in males,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33692086
DOI: 10.1242/dmm.048909
PMCID: PMC8077554

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