Article
BTBR ob/ob mice as a novel diabetic neuropathy model: Neurological characterization and gene expression analyses.
Neurobiology of disease - 1 Jan 2015
O'Brien Phillipe D, Hur Junguk, Hayes John M, Backus Carey, Sakowski Stacey A, Feldman Eva L
Abstract excerpt
Given the lack of treatments for diabetic neuropathy (DN), a common diabetic complication, accurate disease models are necessary. Characterization of the leptin-deficient BTBR ob/ob mouse, a type 2 diabetes model, demonstrated that the mice develop robust diabetes coincident with severe neuropathic features, including nerve conduction deficits and intraepidermal nerve fiber loss by 9 and 13 weeks of age,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.