Article

The generation of viable, structurally integrated human-mouse chimaeras through enhanced hPSCs proliferation

2025-06-25

Abstract excerpt

<h4>SUMMARY</h4> The generation of human organs in animals through blastocyst complementation offers a promising solution to the shortage of transplantable organs. While human pluripotent stem cells (hPSCs) can contribute to interspecies chimaeric embryos when injected into preimplantation embryos of mice, pigs, or monkeys, their integration is often limited due to low chimaerism and segregation from host tissues...

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Literature Corpus work: ce775f59-5981-5891-8e1e-00fa6b6db914
DOI: 10.1101/2025.06.24.661270

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