Article
Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell evolution.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015
Ling Shaoping, Hu Zheng, Yang Zuyu, Yang Fang, Li Yawei, Lin Pei, Chen Ke, Dong Lili, Cao Lihua, Tao Yong, Hao Lingtong, Chen Qingjian, Gong Qiang, Wu Dafei, Li Wenjie, Zhao Wenming, Tian Xiuyun, Hao Chunyi, Hungate Eric A, Catenacci Daniel V T, Hudson Richard R, Li Wen-Hsiung, Lu Xuemei, Wu Chung-I
Abstract excerpt
The prevailing view that the evolution of cells in a tumor is driven by Darwinian selection has never been rigorously tested. Because selection greatly affects the level of intratumor genetic diversity, it is important to assess whether intratumor evolution follows the Darwinian or the non-Darwinian mode of evolution. To provide the statistical power, many regions in a single tumor need to be sampled and analyzed...
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