Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Malaria-Protective Human Glycophorin Structural Variant DUP4 Shows Somatic Mosaicism and Association with Hemoglobin Levels

1 Nov 2018

Abstract excerpt

Glycophorin A and glycophorin B are red blood cell surface proteins and are both receptors for the parasite Plasmodium falciparum, which is the principal cause of malaria in sub-Saharan Africa. DUP4 is a complex structural genomic variant that carries extra copies of a glycophorin A-glycophorin B fusion gene and has a dramatic effect on malaria risk by reducing the risk of severe malaria by up to 40%. Using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hemoglobinopathies and Related Disorders
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30388403
DOI: 10.1016/j.ajhg.2018.10.008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Malaria-Protective Human Glycophorin Structural Variant DUP4 Shows Somatic Mosaicism and Association with Hemoglobin LevelsPMID 30388403Read ↗

The malaria-protective human glycophorin structural variant DUP4 shows somatic mosaicism and association with hemoglobin levelsSemantic proximity Read ↗

Genotyping complex structural variation at the malaria-associated human glycophorin locus using a PCR-based strategy.Semantic proximity Read ↗

Genotyping complex structural variation at the malaria-associated human glycophorin locus using a PCR-based strategySemantic proximity Read ↗

Structural variation of the malaria-associated human glycophorin A-B-E regionSemantic proximity Read ↗

High throughput human genotyping for variants associated with malarial disease outcomes using custom targeted amplicon sequencing.Semantic proximity Read ↗

A bioinformatic analysis of malaria host and pathogen genomicsSemantic proximity Read ↗

Genetic variation of glycophorins and infectious disease.Semantic proximity Read ↗

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African childrenSemantic proximity Read ↗

Whole genome sequencing of Plasmodium vivax isolates reveals frequent sequence and structural polymorphisms in erythrocyte binding genes.Semantic proximity Read ↗

African-specific genetic loci determine iron status and risk of severe malaria and bacteremia in African children.Semantic proximity Read ↗

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and OceaniaSemantic proximity Read ↗

Hemoglobinopathies: Slicing the Gordian Knot of Plasmodium falciparum Malaria PathogenesisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.