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Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

10 May 2021

Abstract excerpt

Myocardial infarction (MI) promotes a range of systemic effects, many of which are unknown. Here, we investigated the alterations associated with MI progression in heart and other metabolically active tissues (liver, skeletal muscle, and adipose) in a mouse model of MI (induced by ligating the left ascending coronary artery) and sham-operated mice. We performed a genome-wide transcriptomic analysis on tissue...

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PMID: 33972017
DOI: 10.7554/elife.66921

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