Article

GSAP regulates mitochondrial function through the Mitochondria-associated ER membrane in the pathogenesis of Alzheimer’s disease

2020-11-18

Abstract excerpt

<h4>ABSTRACT</h4> Biochemical, pathogenic and human genetic data confirm that GSAP (γ-secretase activating protein), a selective γ-secretase modulatory protein, plays important roles in Alzheimer’s disease (AD) and Down syndrome. However, the molecular mechanism(s) underlying GSAP-dependent pathogenesis remains largely elusive. Here, through unbiased proteomics and single-nuclei RNA-seq, we identified that GSAP r...

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Literature Corpus work: ca127329-d65d-589b-9f45-99c3098a7b3a
DOI: 10.1101/2020.11.17.385245

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