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Article

Tau alternative splicing and frontotemporal dementia.

Alzheimer disease and associated disorders - 1 Jan 2000

Kar Amar, Kuo David, He Rongqiao, Zhou Jiawei, Wu Jane Y

Abstract excerpt

A number of neurodegenerative diseases are characterized by the presence of abundant deposits containing Tau protein. Expression of the human tau gene is under complex regulation. Mutations in the tau gene have been identified in patients with frontotemporal lobe dementia. These mutations affect either biochemical/biophysical properties or the delicate balance of different splicing isoforms. In this review, we...

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Identifiers

PMID: 16317255
DOI: 10.1097/01.wad.0000183082.76820.81
PMCID: PMC2001171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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