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Article

Tau exon 10 alternative splicing and tauopathies

1 Jan 2008

Abstract excerpt

Abnormalities of microtubule-associated protein tau play a central role in neurofibrillary degeneration in several neurodegenerative disorders that collectively called tauopathies. Six isoforms of tau are expressed in adult human brain, which result from alternative splicing of pre-mRNA generated from a single tau gene. Alternative splicing of tau exon 10 results in tau isoforms containing either three or four...

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PMID: 18616804
DOI: 10.1186/1750-1326-3-8

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