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Article

Combined genetic and epigenetic alterations of the TERT promoter affect clinical and biological behavior of bladder cancer

23 Oct 2018

Abstract excerpt

In urothelial bladder cancer (UBC), risk stratification remains an important unmet need. Limitless self‐renewal, governed by TERT expression and telomerase activation, is crucial for cancer progression. Thus, telomerase activation through the interplay of mutations (TERTpMut) and epigenetic alterations in the TERT promoter may provide further insight into UBC behavior. Here, we investigated the combined effect of...

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Share to Bladder and Urothelial Cancer Treatments
Share to Epigenetics and DNA Methylation
Share to Telomeres, Telomerase, and Senescence

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Identifiers

PMID: 30350309
DOI: 10.1002/ijc.31935

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