Article
TERT promoter mutations in bladder cancer affect patient survival and disease recurrence through modification by a common polymorphism.
Proceedings of the National Academy of Sciences of the United States of America - 22 Oct 2013
Rachakonda P Sivaramakrishna, Hosen Ismail, de Verdier Petra J, Fallah Mahdi, Heidenreich Barbara, Ryk Charlotta, Wiklund N Peter, Steineck Gunnar, Schadendorf Dirk, Hemminki Kari, Kumar Rajiv
Abstract excerpt
The telomerase reverse transcriptase (TERT) promoter, an important element of telomerase expression, has emerged as a target of cancer-specific mutations. Originally described in melanoma, the mutations in TERT promoter have been shown to be common in certain other tumor types that include glioblastoma, hepatocellular carcinoma, and bladder cancer. To fully define the occurrence and effect of the TERT promoter...
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