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Article

TERT promoter mutations occur early in urothelial neoplasia and are biomarkers of early disease and disease recurrence in urine.

Cancer research - 15 Dec 2013

Kinde Isaac, Munari Enrico, Faraj Sheila F, Hruban Ralph H, Schoenberg Mark, Bivalacqua Trinity, Allaf Mohamad, Springer Simeon, Wang Yuxuan, Diaz Luis A, Kinzler Kenneth W, Vogelstein Bert, Papadopoulos Nickolas, Netto George J

Abstract excerpt

Activating mutations occur in the promoter of the telomerase reverse transcriptase (TERT) gene in 66% of muscle-invasive urothelial carcinomas. To explore their role in bladder cancer development and to assess their utility as urine markers for early detection, we sequenced the TERT promoter in 76 well-characterized papillary and flat noninvasive urothelial carcinomas, including 28 pTa low-grade transitional cell...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Neoplasm Recurrence, Local

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Source

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Identifiers

PMID: 24121487
DOI: 10.1158/0008-5472.CAN-13-2498
PMCID: PMC3966102

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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