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Article

Implications of TERT promoter mutations and telomerase activity in urothelial carcinogenesis.

Nature reviews. Urology - 1 Jun 2018

Günes Cagatay, Wezel Felix, Southgate Jennifer, Bolenz Christian

Abstract excerpt

Telomerase activity imparts eukaryotic cells with unlimited proliferation capacity, one of the cancer hallmarks. Over 90% of human urothelial carcinoma of the bladder (UCB) tumours are positive for telomerase activity. Telomerase activation can occur through several mechanisms. Mutations in the core promoter region of the human telomerase reverse transcriptase gene (TERT) cause telomerase reactivation in 60-80%...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29599449
DOI: 10.1038/s41585-018-0001-5

Genes

TERT

Provenance

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