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Pim1 promotes cell proliferation and regulates glycolysis via interaction with MYC in ovarian cancer

1 Oct 2018

Abstract excerpt

BACKGROUND: Ovarian cancer (OC) is the leading cause of death among women with gynecologic malignancies. Recent studies have highlighted the role of Pim1, which belongs to a group of constitutively activated serine/threonine kinases, in cancer development. However, the effect of Pim1 in OC is largely unclear. METHODS: OC cell lines with Pim1 overexpression or knockdown were constructed with len-tivirus...

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PMID: 30349298
DOI: 10.2147/ott.s180520

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