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Article

Pim1 supports human colorectal cancer growth during glucose deprivation by enhancing the Warburg effect

8 Mar 2018

Abstract excerpt

Cancer cells metabolize glucose mainly by glycolysis and are well adapted to metabolic stress. Pim1 is an oncogene that promotes colorectal cancer (CRC) growth and metastasis, and its expression is positively correlated with CRC progression. However, the mechanism underlying Pim1 overexpression during CRC progression and the role of Pim1 in CRC metabolism remains unclear. In the present study, we discovered that...

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PMID: 29516572
DOI: 10.1111/cas.13562

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