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Testicular endothelial cells are a critical population in the germline stem cell niche

16 Oct 2018

Abstract excerpt

Maintenance of adult tissues depends on stem cell self-renewal in local niches. Spermatogonial stem cells (SSC) are germline adult stem cells necessary for spermatogenesis and fertility. We show that testicular endothelial cells (TECs) are part of the SSC niche producing glial cell line-derived neurotrophic factor (GDNF) and other factors to support human and mouse SSCs in long-term culture. We demonstrate that...

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PMID: 30348976
DOI: 10.1038/s41467-018-06881-z

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