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Article

A long non-coding RNA interacts with Gfra1 and maintains survival of mouse spermatogonial stem cells

10 Mar 2016

Abstract excerpt

Spermatogonial stem cells (SSCs) are unique male germline stem cells that support spermatogenesis and male fertility. Long non-coding RNAs (lncRNA) have been identified as key regulators of stem cell fate; however, their role in SSCs has not been explored. Here, we report that a novel spermatogonia-specific lncRNA (lncRNA033862) is essential for the survival of murine SSCs. LncRNA033862 is expressed in early...

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PMID: 26962690
DOI: 10.1038/cddis.2016.24

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