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Article

Testicular Niche Required for Human Spermatogonial Stem Cell Expansion

18 Jul 2014

Abstract excerpt

Prepubertal boys treated with high-dose chemotherapy do not have an established means of fertility preservation because no established in vitro technique exists to expand and mature purified spermatogonial stem cells (SSCs) to functional sperm in humans. In this study, we define and characterize the unique testicular cellular niche required for SSC expansion using testicular tissues from men with normal...

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PMID: 25038247
DOI: 10.5966/sctm.2014-0045

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