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Article

Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells.

American journal of respiratory cell and molecular biology - 1 Jun 2020

Liu Yiping, Bochkov Yury A, Eickhoff Jens C, Hu Tianchen, Zumwalde Nicholas A, Tan Jin Wen, Lopez Christopher, Fichtinger Paul S, Reddy Thiruchelvi R, Overmyer Katherine A, Gumperz Jennifer E, Coon Joshua, Mathur Sameer K, Gern James E, Smith Judith A

Abstract excerpt

Polymorphism at the 17q21 gene locus and wheezing responses to rhinovirus (RV) early in childhood conspire to increase the risk of developing asthma. However, the mechanisms mediating this gene-environment interaction remain unclear. In this study, we investigated the impact of one of the 17q21-encoded genes, ORMDL3 (orosomucoid-like 3), on RV replication in human epithelial cells. ORMDL3 knockdown inhibited...

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Identifiers

PMID: 32078788
DOI: 10.1165/rcmb.2019-0237OC
PMCID: PMC7258826

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