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Evaluating the Therapeutic Efficacy of Iopanoic Acid in a DMM-Induced Osteoarthritis Mouse Model and Osteochondral Lesioned Human Explants

2025-07-18

Abstract excerpt

<h4>Objective: </h4> To evaluate the therapeutic potential of iopanoic acid (IOP), a thyroid hormone pathway inhibitor, in preserving cartilage and bone integrity in osteoarthritis (OA), using in vivo and ex vivo tissue models. <h4>Design:</h4> In the DMM mouse model, IOP was administered through intra-articular (i.a.) injection, either alone or combined with a thermosensitive hydrogel to enable sustained release....

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Identifiers and source

Literature Corpus work
6498981a-a7f4-5dc3-9d56-e0ef20eb7d5b
DOI
10.1101/2025.07.15.663868
Open publication

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