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Article

CACNA1C risk variant affects reward responsiveness in healthy individuals.

Translational psychiatry - 7 Oct 2014

Lancaster T M, Heerey E A, Mantripragada K, Linden D E J

Abstract excerpt

The variant at rs1006737 in the L-type voltage-gated calcium channel (alpha 1c subunit) CACNA1C gene is reliably associated with both bipolar disorder and schizophrenia. We investigated whether this risk variant affects reward responsiveness because reward processing is one of the central cognitive-motivational domains implicated in both disorders. In a sample of 164 young, healthy individuals, we show a...

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Identifiers

PMID: 25290268
DOI: 10.1038/tp.2014.100
PMCID: PMC4350510

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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