Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

IFITM proteins inhibit HIV-1 protein synthesis

24 Sept 2018

Abstract excerpt

Interferon induced transmembrane proteins (IFITMs) inhibit the cellular entry of a broad range of viruses, but it has been suspected that for HIV-1 IFITMs may also inhibit a post-integration replicative step. We show that IFITM expression reduces HIV-1 viral protein synthesis by preferentially excluding viral mRNA transcripts from translation and thereby restricts viral production. Codon-optimization of proviral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to HIV Research and Treatment
Share to interferon and immune responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30266929
DOI: 10.1038/s41598-018-32785-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

IFITM proteins inhibit HIV-1 protein synthesisPMID 30266929Read ↗

IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivitySemantic proximity Read ↗

More than meets the I: the diverse antiviral and cellular functions of interferon-induced transmembrane proteinsSemantic proximity Read ↗

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.Semantic proximity Read ↗

Translation Inhibition Mediated by Interferon-Stimulated Genes during Viral InfectionsSemantic proximity Read ↗

HIV-1 mutates to evade IFITM1 restriction.Semantic proximity Read ↗

IFITM proteins: Understanding their diverse roles in viral infection, cancer, and immunitySemantic proximity Read ↗

Δ20 IFITM2 differentially restricts X4 and R5 HIV-1.Semantic proximity Read ↗

Resistance of Transmitted Founder HIV-1 to IFITM-Mediated Restriction.Semantic proximity Read ↗

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cellsSemantic proximity Read ↗

Natural mutations in IFITM3 modulate post-translational regulation and toggle antiviral specificity.Semantic proximity Read ↗

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cellsSemantic proximity Read ↗

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cellsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.