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Article

Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells

15 May 2019

Abstract excerpt

<h4>Background: </h4> Norovirus, also known as the winter vomiting bug, is the predominant cause of non-bacterial gastroenteritis worldwide. Disease control is predicated on a robust innate immune response during the early stages of infection. Double-stranded RNA intermediates generated during viral genome replication are recognised by host innate immune sensors in the cytoplasm, activating the strongly antiviral...

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PMID: 31372503
DOI: 10.12688/wellcomeopenres.15223.1

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