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Article

IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon.

PLoS pathogens - 1 Apr 2015

Reynaud Josephine M, Kim Dal Young, Atasheva Svetlana, Rasalouskaya Aliaksandra, White James P, Diamond Michael S, Weaver Scott C, Frolova Elena I, Frolov Ilya

Abstract excerpt

Alphaviruses are a group of widely distributed human and animal pathogens. It is well established that their replication is sensitive to type I IFN treatment, but the mechanism of IFN inhibitory function remains poorly understood. Using a new experimental system, we demonstrate that in the presen...

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Identifiers

PMID: 25927359
DOI: 10.1371/journal.ppat.1004863
PMCID: PMC4415776

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25927359-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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