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Article

Loss of GATA6 leads to nuclear deformation and aneuploidy in ovarian cancer.

Molecular and cellular biology - 1 Sept 2009

Capo-chichi Callinice D, Cai Kathy Q, Testa Joseph R, Godwin Andrew K, Xu Xiang-Xi

Abstract excerpt

A prominent hallmark of most human cancer is aneuploidy, which is a result of the chromosomal instability of cancer cells and is thought to contribute to the initiation and progression of most carcinomas. The developmentally regulated GATA6 transcription factor is commonly lost in ovarian cancer, and the loss of its expression is closely associated with neoplastic transformation of the ovarian surface epithelium....

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Source

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Identifiers

PMID: 19581290
DOI: 10.1128/MCB.00087-09
PMCID: PMC2725711

Genes

GATA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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