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Article

The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope

4 Feb 2019

Abstract excerpt

During meiotic prophase I, telomeres attach to and move on the nuclear envelope (NE), regulating chromosome movement to promote homologous pairing. Meiosis-specific proteins TERB1, TERB2 and MAJIN play a key role in this process. Here, we report the crystal structures of human TERB1-TERB2 and TERB2-MAJIN subcomplexes. Specific disruption of the TERB1-TERB2 or the TERB2-MAJIN interaction in the mouse Terb2 gene...

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PMID: 30718482
DOI: 10.1038/s41467-019-08437-1

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