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Article

The Drosophila nuclear lamina protein otefin is required for germline stem cell survival.

Developmental cell - 24 Jun 2013

Barton Lacy J, Pinto Belinda S, Wallrath Lori L, Geyer Pamela K

Abstract excerpt

LEM domain (LEM-D) proteins are components of an extensive protein network that assembles beneath the inner nuclear envelope. Defects in LEM-D proteins cause tissue-restricted human diseases associated with altered stem cell homeostasis. Otefin (Ote) is a Drosophila LEM-D protein that is intrinsically required for female germline stem cell (GSC) maintenance. Previous studies linked Ote loss with transcriptional...

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Identifiers

PMID: 23806619
DOI: 10.1016/j.devcel.2013.05.023
PMCID: PMC3710436

Genes

GSC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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