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Article

RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate Cancer

26 Sept 2018

Abstract excerpt

Abstract Purpose: Metastatic castration-resistant prostate cancer (mCRPC) is a lethal but clinically heterogeneous disease, with patients having variable benefit from endocrine and cytotoxic treatments. Intrapatient genomic heterogeneity could be a contributing factor to this clinical heterogeneity. Here, we used whole-genome sequencing (WGS) to investigate genomic heterogeneity in 21 previously treated CRPC...

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PMID: 30257982
DOI: 10.1158/1078-0432.ccr-18-2068

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