Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing.

doi:10.1016/j.cell.2018.05.036

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Article

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing.

Cell - 12 Jul 2018

Viswanathan Srinivas R, Ha Gavin, Hoff Andreas M, Wala Jeremiah A, Carrot-Zhang Jian, Whelan Christopher W, Haradhvala Nicholas J, Freeman Samuel S, Reed Sarah C, Rhoades Justin, Polak Paz, Cipicchio Michelle, Wankowicz Stephanie A, Wong Alicia, Kamath Tushar, Zhang Zhenwei, Gydush Gregory J, Rotem Denisse, Love J Christopher, Getz Gad, Gabriel Stacey, Zhang Cheng-Zhong, Dehm Scott M, Nelson Peter S, Van Allen Eliezer M, Choudhury Atish D, Adalsteinsson Viktor A, Beroukhim Rameen, Taplin Mary-Ellen, Meyerson Matthew

Abstract excerpt

Nearly all prostate cancer deaths are from metastatic castration-resistant prostate cancer (mCRPC), but there have been few whole-genome sequencing (WGS) studies of this disease state. We performed linked-read WGS on 23 mCRPC biopsy specimens and analyzed cell-free DNA sequencing data from 86 patients with mCRPC. In addition to frequent rearrangements affecting known prostate cancer genes, we observed complex...

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PMID: 29909985
DOI: 10.1016/j.cell.2018.05.036
PMCID: PMC6046279

Genes

CDK12
MYC

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