The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.

doi:10.1038/s41467-019-13084-7

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.

Nature communications - 20 Nov 2019

van Dessel Lisanne F, van Riet Job, Smits Minke, Zhu Yanyun, Hamberg Paul, van der Heijden Michiel S, Bergman Andries M, van Oort Inge M, de Wit Ronald, Voest Emile E, Steeghs Neeltje, Yamaguchi Takafumi N, Livingstone Julie, Boutros Paul C, Martens John W M, Sleijfer Stefan, Cuppen Edwin, Zwart Wilbert, van de Werken Harmen J G, Mehra Niven, Lolkema Martijn P

Abstract excerpt

Metastatic castration-resistant prostate cancer (mCRPC) has a highly complex genomic landscape. With the recent development of novel treatments, accurate stratification strategies are needed. Here we present the whole-genome sequencing (WGS) analysis of fresh-frozen metastatic biopsies from 197 mCRPC patients. Using unsupervised clustering based on genomic features, we define eight distinct genomic clusters. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation Sequencing

Share to Cyclin-Dependent Kinases

Share to Lymph Nodes

Share to Oncogene Proteins, Fusion

Share to Prostatic Neoplasms, Castration-Resistant

Share to Recombinational DNA Repair

Share to Soft Tissue Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 31748536
DOI: 10.1038/s41467-019-13084-7
PMCID: PMC6868175

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact.PMID 31748536Read ↗

The genomic landscape of metastatic castration-resistant prostate cancers using whole genome sequencing reveals multiple distinct genotypes with potential clinical impactSemantic proximity Read ↗

Structural Alterations Driving Castration-Resistant Prostate Cancer Revealed by Linked-Read Genome Sequencing.Semantic proximity Read ↗

RB1 Heterogeneity in Advanced Metastatic Castration-Resistant Prostate CancerSemantic proximity Read ↗

Genomic Hallmarks and Structural Variation in Metastatic Prostate Cancer.Semantic proximity Read ↗

Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories.Semantic proximity Read ↗

A comprehensive review of genomic landscape, biomarkers and treatment sequencing in castration-resistant prostate cancerSemantic proximity Read ↗

Patterns of Structural Variation Define Prostate Cancer Across Disease StatesSemantic proximity Read ↗

Patterns of structural variation define prostate cancer across disease statesSemantic proximity Read ↗

Genomic Determinants of Lethality and Therapeutic Vulnerability in Castration-Resistant Prostate CancerSemantic proximity Read ↗

Prospective Genomic Profiling of Prostate Cancer Across Disease States Reveals Germline and Somatic Alterations That May Affect Clinical Decision MakingSemantic proximity Read ↗

Genomic characterization of metastatic castration‐resistant prostate cancer patients undergoing PSMA radioligand therapy: A single‐center experienceSemantic proximity Read ↗

Genomic Alteration Burden in Advanced Prostate Cancer and Therapeutic ImplicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.