Article
Genomic Heterogeneity Within Individual Prostate Cancer Foci Impacts Predictive Biomarkers of Targeted Therapy.
European urology focus - 1 May 2019
VanderWeele David J, Finney Richard, Katayama Kotoe, Gillard Marc, Paner Gladell, Imoto Seiya, Yamaguchi Rui, Wheeler David, Lack Justin, Cam Maggie, Pontier Andrea, Nguyen Yen Thi Minh, Maejima Kazuhiro, Sasaki-Oku Aya, Nakano Kaoru, Tanaka Hiroko, Vander Griend Donald, Kubo Michiaki, Ratain Mark J, Miyano Satoru, Nakagawa Hidewaki
Abstract excerpt
BACKGROUND: Most lethal prostate cancers progress from relapse of aggressive primary disease. Recently, the most significant advances in survival benefit from systemic therapy have come from moving the administration of therapy to an earlier disease state. There is movement toward using biomarkers from the intraprostatic index lesion to guide early systemic therapy. OBJECTIVE: To determine the genomic...
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