Article
Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria.
Scientific reports - 14 Sept 2018
Kano Flora Satiko, de Souza Aracele Maria, de Menezes Torres Leticia, Costa Marcelo Azevedo, Souza-Silva Flávia Alessandra, Sanchez Bruno Antônio Marinho, Fontes Cor Jesus Fernandes, Soares Irene Silva, de Brito Cristiana Ferreira Alves, Carvalho Luzia Helena, Sousa Tais Nobrega
Abstract excerpt
Malaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Africa and confers resistance to Plasmodium vivax infection. Here, we showed the influence of genomic ancestry on the...
Topics
- Adolescent
- Adult
- Antibodies, Protozoan
- Child
- Cohort Studies
- Duffy Blood-Group System
- Environmental Exposure
- Female
- Genetic Predisposition to Disease