Article
Population genetic analysis of the DARC locus (Duffy) reveals adaptation from standing variation associated with malaria resistance in humans.
PLoS genetics - 1 Mar 2017
McManus Kimberly F, Taravella Angela M, Henn Brenna M, Bustamante Carlos D, Sikora Martin, Cornejo Omar E
Abstract excerpt
The human DARC (Duffy antigen receptor for chemokines) gene encodes a membrane-bound chemokine receptor crucial for the infection of red blood cells by Plasmodium vivax, a major causative agent of malaria. Of the three major allelic classes segregating in human populations, the FY*O allele has been shown to protect against P. vivax infection and is at near fixation in sub-Saharan Africa, while FY*B and FY*A are...
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