Article
Acquired antibody responses against Plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (DARC).
PloS one - 15 Jul 2010
Maestre Amanda, Muskus Carlos, Duque Victoria, Agudelo Olga, Liu Pu, Takagi Akihide, Ntumngia Francis B, Adams John H, Sim Kim Lee, Hoffman Stephen L, Corradin Giampietro, Velez Ivan D, Wang Ruobing
Abstract excerpt
BACKGROUND: Polymorphism of the Duffy Antigen Receptor for Chemokines (DARC) is associated with susceptibility to and the severity of Plasmodium vivax malaria in humans. P. vivax uses DARC to invade erythrocytes. Individuals lacking DARC are 'resistant' to P. vivax erythrocytic infection. However...
Topics
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Duffy Blood-Group System
- Enzyme-Linked Immunosorbent Assay
- Genotype
- Humans
- Immunoglobulin G
- Immunoglobulin M
- Malaria, Vivax
- Merozoite Surface Protein 1
- Plasmodium falciparum
- Plasmodium vivax