Article
Fy(a)/Fy(b) antigen polymorphism in human erythrocyte Duffy antigen affects susceptibility to Plasmodium vivax malaria.
Proceedings of the National Academy of Sciences of the United States of America - 13 Dec 2011
King Christopher L, Adams John H, Xianli Jia, Grimberg Brian T, McHenry Amy M, Greenberg Lior J, Siddiqui Asim, Howes Rosalind E, da Silva-Nunes Monica, Ferreira Marcelo U, Zimmerman Peter A
Abstract excerpt
Plasmodium vivax (Pv) is a major cause of human malaria and is increasing in public health importance compared with falciparum malaria. Pv is unique among human malarias in that invasion of erythrocytes is almost solely dependent on the red cell's surface receptor, known as the Duffy blood-group antigen (Fy). Fy is an important minor blood-group antigen that has two immunologically distinct alleles, referred to...
Topics
- Antibodies, Blocking
- Antibodies, Protozoan
- Antigens, Protozoan
- Arylsulfatases
- Duffy Blood-Group System
- Erythrocytes
- Gene Frequency
- Genetic Predisposition to Disease
- Geography