Article
A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype.
Blood - 1 Oct 1998
Parasol N, Reid M, Rios M, Castilho L, Harari I, Kosower N S
Abstract excerpt
The Duffy blood group system is of clinical and biological significance. Antibodies to Duffy antigens are responsible for some cases of transfusion incompatibility and newborn hemolytic disease. The Duffy protein is a receptor for the Plasmodium vivax erythrocyte-binding protein and is also a receptor for various chemokines (thus renamed Duffy Antigen Receptor for Chemokines [DARC]). The two Duffy polymorphic...
Topics
- Agglutination Tests
- Alleles
- Animals
- Antigens, Protozoan
- Binding Sites
- Black People
- Brazil
- Carrier Proteins
- DNA Mutational Analysis
- DNA-Binding Proteins
- Disease Susceptibility
- Duffy Blood-Group System
- Erythrocyte Membrane