Article
Detection of the signature of natural selection in humans: evidence from the Duffy blood group locus.
American journal of human genetics - 1 May 2000
Hamblin M T, Di Rienzo A
Abstract excerpt
The Duffy blood group locus, which encodes a chemokine receptor, is characterized by three alleles-FY*A, FY*B, and FY*O. The frequency of the FY*O allele, which corresponds to the absence of Fy antigen on red blood cells, is at or near fixation in most sub-Saharan African populations but is very rare outside Africa. The FST value for the FY*O allele is the highest observed for any allele in humans, providing...
Topics
- Africa South of the Sahara
- Alleles
- Animals
- Base Sequence
- Duffy Blood-Group System
- Gene Frequency
- Genetic Variation
- Haplotypes
- Humans
- Italy
- Models, Genetic
- Mutation