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Article

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes.

Aging cell - 1 Dec 2018

Griveau Audrey, Wiel Clotilde, Le Calvé Benjamin, Ziegler Dorian V, Djebali Sophia, Warnier Marine, Martin Nadine, Marvel Jacqueline, Vindrieux David, Bergo Martin O, Bernard David

Abstract excerpt

Hutchinson-Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates many normal aging characteristics. This disorder is caused by mutation in the LMNA gene leading to the production of progerin which induces misshapen nuclei, cellular senescence, and aging. We previously showed that the phospholipase A2 receptor (PLA2R1) promotes senescence induced by replicative, oxidative, and oncogenic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30216637
DOI: 10.1111/acel.12835
PMCID: PMC6260922

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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